![]() ![]() Noningestion routes of exposure, information requests, exposures with unknown age, and nonhuman exposures were excluded. Aggregate national data were abstracted from NPDS ( 5). A closed case is one for which the regional poison control center determined that either no further follow-up or recommendations were required or no further information on the case was available ( 5). All closed cases of single substance melatonin ingestions (generic code 0201106) involving children, adolescents, and young adults aged ≤19 years during January 1, 2012–December 31, 2021, were included ( 5). This was a cross-sectional study of pediatric melatonin ingestions reported to U.S. Public health initiatives should focus on raising awareness of increasing numbers of melatonin ingestions among children and on the development of preventive measures to eliminate this risk. Consumers and health care professionals should be encouraged to report any melatonin product–related adverse events to MedWatch, the FDA’s medical product safety reporting program. Five children required mechanical ventilation, and two died. Pediatric hospitalizations and more serious outcomes due to melatonin ingestions increased during the study period, primarily related to an increase in unintentional ingestions among children aged ≤5 years. In addition, pediatric melatonin ingestions accounted for 4.9% of all pediatric ingestions reported to poison control centers in 2021 compared with 0.6% in 2012. During the 10-year study period, 260,435 pediatric melatonin ingestions were reported to NPDS, and the annual number of ingestions increased 530%. This study assessed isolated melatonin ingestions among the pediatric population (defined here as children, adolescents, and young adults aged ≤19 years) during January 1, 2012–December 31, 2021, using the American Association of Poison Control Centers’ National Poison Data System (NPDS). In 2020, melatonin became the most frequently ingested substance among children reported to national poison control centers ( 4) however, more research is needed to describe the toxicity and outcomes associated with melatonin ingestions in children. ![]() Children are at increased risk for melatonin exposure because of the supplement’s widespread use and growing popularity as a sleep aid. Various synthetic melatonin preparations are widely available over the counter (OTC) in the United States with sales increasing from $285 million in 2016 to $821 million in 2020 ( 3). Melatonin is regulated by the Food and Drug Administration (FDA) as a dietary supplement. It is used therapeutically for insomnia in adults and for primary sleep disorders in children ( 2). Melatonin is an endogenous neurohormone that regulates the sleep-wake cycle ( 1). ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |